Daniel T M, Pizzo S V, Mckee P A
Ann Surg. 1976 Aug;184(2):223-8. doi: 10.1097/00000658-197608000-00015.
An experimental model of surgically-induced arterial thrombosis was devised using the femoral arteries of dogs. Within 7 days, 67% of the arteries became completely thrombosed and only 12% remained compeletly patent. In the group of dogs that received low-dose heparin, 69% of the vessels were completely thrombosed and 6% remained completely patent. In the group of dogs treated with low-dose Ancrod to induce partial defibrination, 75% remained completely patent while only 19% of their femoral arteries were completely thrombosed. Although the ancrod was effective in preventing arterial thrombosis, 88% of the wounds showed moderate to severe separations. Most likely the absence of a fibrin lattice, necessary for the securement and growth of fibroblasts as the wound heals, explains this latter effect. Thus while Ancrod may become useful as an anticoagulant in certain clinical situations, it should not be used in proximity to surgery. Finally, in these studies of acute arterial thromboses, low-dose heparin therapy offered no protective effect.
利用狗的股动脉设计了一种手术诱导动脉血栓形成的实验模型。在7天内，67%的动脉完全形成血栓，只有12%仍完全通畅。在接受低剂量肝素的狗组中，69%的血管完全形成血栓，6%仍完全通畅。在用低剂量Ancrod诱导部分纤维蛋白溶解治疗的狗组中，75%仍完全通畅，而其股动脉只有19%完全形成血栓。虽然Ancrod在预防动脉血栓形成方面有效，但88%的伤口出现中度至重度裂开。很可能在伤口愈合时，成纤维细胞的固定和生长所必需的纤维蛋白网的缺失解释了后一种效应。因此，虽然Ancrod在某些临床情况下可能作为抗凝剂有用，但它不应在手术附近使用。最后，在这些急性动脉血栓形成的研究中，低剂量肝素治疗没有提供保护作用。
