由赛米利疱疹病毒C488独立引发的T细胞淋巴瘤，与ie14/vsag无关，ie14/vsag是一种具有超抗原同源性的病毒基因。
T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology.
作者信息
Knappe A, Thurau M, Niphuis H, Hiller C, Wittmann S, Kuhn E M, Rosenwirth B, Fleckenstein B, Heeney J, Fickenscher H
机构信息
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
出版信息
J Virol. 1998 Apr;72(4):3469-71. doi: 10.1128/JVI.72.4.3469-3471.1998.
Abstract
The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.
摘要
猴疱疹病毒的即刻早期基因ie14/vsag与小鼠超抗原具有同源性。我们比较了棉顶狨猴（Saguinus oedipus）感染ie14/vsag缺失突变体或野生型病毒C488后的发病机制。感染两周后，所有动物均独立于病毒ie14/vsag基因的存在而发展为急性T细胞淋巴瘤。
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