Arsenijevic Y, Tribollet E
Department of Physiology, University Medical Centre, 9 Avenue de Champel, 1211 Geneva 4, Switzerland.
Brain Res. 1998 Feb 23;785(1):167-70. doi: 10.1016/s0006-8993(97)01429-7.
We reported previously a significant reduction of oxytocin (OT) receptor binding in the brain of 20-month old rats relative to 3-month old ones. The present study shows that testosterone treatment of aging rats restores normal adult levels of OT receptor binding in the olfactory tubercle and in the hypothalamic ventromedial nucleus, but not in the caudate-putamen. These data indicate that the reduced plasma testosterone found in 20-month old rats is responsible for the loss of OT receptors in the olfactory tubercle and hypothalamic ventromedial nucleus, whereas other aging-related mechanisms may account for the decrease of OT receptor binding in the caudate-putamen.
我们之前报道过，与3个月大的大鼠相比，20个月大的大鼠大脑中催产素（OT）受体结合显著减少。本研究表明，对老龄大鼠进行睾酮治疗可使嗅结节和下丘脑腹内侧核中的OT受体结合恢复到正常成年水平，但尾状核-壳核中则不然。这些数据表明，20个月大的大鼠体内血浆睾酮水平降低是导致嗅结节和下丘脑腹内侧核中OT受体丢失的原因，而其他与衰老相关的机制可能是尾状核-壳核中OT受体结合减少的原因。
