Makhay M M, Young A M, Poling A
Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130-3932, USA.
Exp Clin Psychopharmacol. 1998 Feb;6(1):3-9. doi: 10.1037//1064-1297.6.1.3.
Pigeons were trained in a 3-choice assay to discriminate among injections of 5.6 mg/kg U-50,488H, 5.6 mg/kg morphine, and vehicle solution. In dose-response tests, subjects rarely responded on the U-50,488H-appropriate key when morphine was administered or on the morphine-appropriate key when they received U-50,488H. A high dose of naltrexone (1.0 mg/kg) completely blocked the morphine cue but failed to block completely the U-50,488H cue. In generalization tests, d-amphetamine primarily engendered saline-appropriate responding. Ethylketazocine produced mixed results, in that moderate doses produced responding on both the morphine- and U-50,488H-appropriate keys, but 3.2 mg/kg engendered primarily morphine-appropriate responding. These results demonstrate the feasibility, but not necessarily the value, of 3-choice discrimination procedures involving mu and kappa agonists and vehicle.
鸽子在一项三选一试验中接受训练，以区分注射5.6毫克/千克的U-50,488H、5.6毫克/千克的吗啡和溶媒溶液。在剂量反应测试中，当给予吗啡时，受试对象很少在与U-50,488H对应的按键上做出反应；当接受U-50,488H时，也很少在与吗啡对应的按键上做出反应。高剂量的纳曲酮（1.0毫克/千克）完全阻断了吗啡线索，但未能完全阻断U-50,488H线索。在泛化测试中，右旋苯丙胺主要引发与生理盐水对应的反应。乙基酮佐辛产生了混合结果，即中等剂量会在与吗啡和U-50,488H对应的按键上都引发反应，但3.2毫克/千克主要引发与吗啡对应的反应。这些结果证明了涉及μ和κ激动剂及溶媒的三选一辨别程序的可行性，但不一定证明其价值。
