Kesäniemi Y A
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland.
Am J Cardiol. 1998 Feb 26;81(4A):70B-73B. doi: 10.1016/s0002-9149(98)00042-3.
Trial evidence shows that effective lowering of serum total cholesterol and particularly of low-density lipoprotein (LDL) cholesterol is important for the prevention of total mortality, coronary artery disease mortality, and major coronary events. The role of serum triglyceride reduction in achieving clinical benefit is unclear and poorly documented. On the other hand, no specific trials have studied the importance of triglyceride lowering among patients with marked hypertriglyceridemia. One of the problems in assessing patients with high serum triglyceride levels may be the heterogeneous background of the molecular mechanisms that result in hypertriglyceridemia.
试验证据表明，有效降低血清总胆固醇，尤其是低密度脂蛋白（LDL）胆固醇，对于预防总死亡率、冠状动脉疾病死亡率和主要冠状动脉事件至关重要。降低血清甘油三酯在实现临床益处方面的作用尚不清楚，且记录不足。另一方面，尚无具体试验研究在明显高甘油三酯血症患者中降低甘油三酯的重要性。评估血清甘油三酯水平高的患者时存在的问题之一可能是导致高甘油三酯血症的分子机制背景存在异质性。
