Sköld K, Twetman S, Hallgren A, Yucel-Lindberg T, Modéer T
Department of Orthodontics, Medical and Dental Center, Halmstad, Sweden.
Eur J Oral Sci. 1998 Feb;106(1):571-5. doi: 10.1046/j.0909-8836.1998.eos106106.x.
The aim was to study the effect of a chlorhexidine/thymol-containing varnish (Cervitec) on the levels of prostaglandin E2 (PGE2) in gingival crevicular fluid (GCF). The material consisted of 25 adolescents and young adults with fixed orthodontic appliances exhibiting gingival inflammation. Four buccal sites, adjacent to bands and brackets, were selected on each patient and randomly treated with either a varnish containing chlorhexidine diacetate (1% w/w) and thymol (1% w/w) or a placebo varnish without active ingredients. After baseline registration, the varnishes were applied twice within 3 d. Follow-up examinations were performed after 3, 8 and 30 d. The gingival inflammation was assessed by bleeding on probing, volume of GCF with a Periotron 8000 and PGE2 level in GCF by using a radioimmuno assay. Compared with baseline, a statistically significant reduction in the volume of GCF was recorded at the chlorhexidine/thymol treated sites in contrast to the placebo. The mean PGE2 levels were significantly reduced after the test varnish treatment compared with baseline and differed significantly from placebo after 8 d. The findings suggest that treatments with the antibacterial varnish result in reduced gingival inflammation and may thus be beneficial for patients with fixed orthodontic appliances.
目的是研究含氯己定/百里酚的清漆（Cervitec）对龈沟液（GCF）中前列腺素E2（PGE2）水平的影响。研究材料包括25名患有牙龈炎症且佩戴固定正畸矫治器的青少年和年轻成年人。在每位患者身上，选择与带环和托槽相邻的四个颊侧部位，并随机用含双乙酸氯己定（1% w/w）和百里酚（1% w/w）的清漆或无活性成分的安慰剂清漆进行处理。在基线记录后，在3天内将清漆涂抹两次。在3、8和30天后进行随访检查。通过探诊出血评估牙龈炎症，使用Periotron 8000测量龈沟液量，并通过放射免疫测定法测量龈沟液中的PGE2水平。与基线相比，氯己定/百里酚处理部位的龈沟液量有统计学意义的显著减少，而安慰剂组则无此现象。与基线相比，测试清漆处理后平均PGE2水平显著降低，且在8天后与安慰剂组有显著差异。研究结果表明，使用抗菌清漆进行治疗可减轻牙龈炎症，因此可能对佩戴固定正畸矫治器的患者有益。
