Wandzel L
Prywatny Gabinet Psychiatryczny w Białymstoku.
Psychiatr Pol. 1997 Jul-Aug;31(4):429-35.
20 obsessive-compulsive patients (OCD according to DSM IV) were treated with fluoxetine. The efficacy of the 3-month treatment was evaluated by Yale-Brown Obsessive Compulsive Rating Scale (Y-BOCS). The average of the Y-BOCS was 26.9 at the beginning of the treatment. The intensity of the OCD was radically lower after the first month of the treatment. The average of the Y-BOCS was 26.9 at the beginning of the treatment. The intensity of the OCD was radically lower after the first month of the treatment. The average of the Y-BOCS was 18.7 (difference statistically significant). The similar difference of the intensity of OCD was noticed after the second month of the treatment with fluoxetine. The average of the Y-BOCS was 12.9 (difference statistically significant). The average of the Y-BOCS after the third month of treatment with fluoxetine was only 9.1. The intensity of OCD after 3 months of treatment with fluoxetine was clinically insignificant in 60% of the patients and in 35% it was mild. The result of the 17-item Hamilton Depression Scale was low and was not changed statistically during 3 months, treatment with fluoxetine. The results confirm the antiobsessional activity of fluoxetine, particularly in the second month of the treatment. Fluoxetine can be very useful in the treatment of OCD.
20名强迫症患者（根据《精神疾病诊断与统计手册第四版》诊断为强迫症）接受了氟西汀治疗。采用耶鲁-布朗强迫症评定量表（Y-BOCS）评估3个月治疗的疗效。治疗开始时Y-BOCS的平均值为26.9。治疗第一个月后，强迫症的严重程度大幅降低。治疗开始时Y-BOCS的平均值为26.9。治疗第一个月后，强迫症的严重程度大幅降低。Y-BOCS的平均值为18.7（差异具有统计学意义）。在使用氟西汀治疗的第二个月后，观察到强迫症严重程度有类似差异。Y-BOCS的平均值为12.9（差异具有统计学意义）。使用氟西汀治疗三个月后Y-BOCS的平均值仅为9.1。使用氟西汀治疗3个月后，60%的患者强迫症严重程度在临床上无显著意义，35%的患者为轻度。17项汉密尔顿抑郁量表的结果较低，在使用氟西汀治疗的3个月期间无统计学变化。结果证实了氟西汀的抗强迫作用，尤其是在治疗的第二个月。氟西汀在强迫症治疗中可能非常有用。
