Montoya-Molina C E, Sepúlveda-Méndez J, Arteaga-de-Murphy C, Meléndez-Alafort L, Rojas-Bautista J C, López-Alvarenga J C
Departamento de Medicina Nuclear y Clínica de Tiroides, Instituto Nacional de Nutrición Salvador Zubirán, México, D.F., México.
Rev Invest Clin. 1997 Sep-Oct;49(5):373-7.
To compare the quality of bone scans obtained with 99mTc-ABP, a new radiopharmaceutical, and 99mTc-MDP.
A comparative study within subjects was done in nine healthy volunteers, 5 female and 4 male, aged 23 to 39 years. The dose for both radiopharmaceuticals was 740 MBq; radiopharmacokinetic parameters were determined and a whole body bone scan was taken with a MultiSpect 2 gamma camera two hours post administration with a wash-out period of 72 hours between preparations. The images were independently evaluated by three nuclear medicine physicians by drawing of regions of interest (ROIs) on vertebrae, ribs, femur, sternum, joints and skull. Ratios bone/soft tissue were obtained drawing ROIs on several bones. The kappa test and the Wilcoxon rank test were used for statistical comparisons.
The agreement on the quality of the images with Tc-ABP and Tc-MDP was fair (kappa 0.4). The femur/soft tissue ratio had a normal distribution and the Wilcoxon test showed no statistical difference between preparations.
Even though bone uptake was higher and faster with Tc-ABP, the quality of the scans obtained with either radiopharmaceutical was similar. We recommend the use of Tc-ABP as a routine bone scan agent because of its less radiation exposure to the patient.
比较新型放射性药物99mTc - ABP和99mTc - MDP所获得的骨扫描质量。
对9名健康志愿者（5名女性和4名男性，年龄23至39岁）进行了一项受试者内比较研究。两种放射性药物的剂量均为740 MBq；测定放射性药代动力学参数，并在给药后两小时用MultiSpect 2γ相机进行全身骨扫描，两次检查之间的洗脱期为72小时。三名核医学医生通过在椎骨、肋骨、股骨、胸骨、关节和颅骨上绘制感兴趣区域（ROI）对图像进行独立评估。通过在多块骨骼上绘制ROI获得骨/软组织比值。采用kappa检验和Wilcoxon秩和检验进行统计学比较。
Tc - ABP和Tc - MDP图像质量的一致性一般（kappa值为0.4）。股骨/软组织比值呈正态分布，Wilcoxon检验显示两种制剂之间无统计学差异。
尽管Tc - ABP的骨摄取更高且更快，但两种放射性药物所获得的扫描质量相似。由于其对患者的辐射暴露较少，我们建议将Tc - ABP用作常规骨扫描剂。
