Alegre M, Noé E, Luquin M R
Departamento de Neurología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Rev Med Univ Navarra. 1997 Jan-Mar;41(1):46-57.
Alzheimer's disease (AD) is a multifactorial entity with a complex pathogeny. Recent findings on this subject are discussed in this article, centering mainly on genetic factors, cerebral ischemia and their association with the most typical histologic lesions in AD. Finally, a hypothetical model is proposed, in which beta-amyloid represents the key element.
阿尔茨海默病（AD）是一种病因复杂的多因素疾病。本文讨论了关于该疾病的最新研究发现，主要围绕遗传因素、脑缺血及其与AD最典型组织学病变的关联展开。最后，提出了一个假说模型，其中β-淀粉样蛋白是关键因素。
