Gad C
Br J Obstet Gynaecol. 1976 Jul;83(7):554-9. doi: 10.1111/j.1471-0528.1976.tb00885.x.
This report concerns 375 patients seen in Frederiksberg, Denmark, between 1951 and 1972: 103 of them had severe dysplasia and 272 of them carcinoma in situ of the uterine cervix. Thirty patients had no primary treatment: 9 of them developed invasive carcinoma, and 2 of these died; 12 patients had persistent intraepithelial abnormality of the cervix and the other 9 patients showed no abnormality after varying periods of observation. Recurrences after cone biopsy were noted in 9.5 and 10.1 per cent of patients with severe dysplasia and carcinoma in situ respectively, and in 2 per cent of patients who had an in situ carcinoma treated by hysterectomy. This made a total of 15 patients with recurrences. All were ultimately cured although two patients were found to have invasive carcinoma.
本报告涉及1951年至1972年间在丹麦腓特烈斯贝就诊的375例患者：其中103例有严重发育异常，272例为宫颈原位癌。30例患者未接受初始治疗：其中9例发展为浸润癌，2例死亡；12例患者宫颈上皮内异常持续存在，另外9例患者在不同观察期后未显示异常。锥切活检后，严重发育异常和原位癌患者的复发率分别为9.5%和10.1%，子宫切除治疗原位癌的患者复发率为2%。共有15例患者复发。尽管有2例患者被发现患有浸润癌，但所有患者最终均治愈。
