Gómez-García A O, Fernández-Concepción O, Milán-Ginjauma E
Instituto Nacional de Neurología y Neurocirugía, Ciudad de la Habana, Cuba.
Rev Neurol. 1997 Dec;25(148):1863-6.
Multiple sclerosis (MS) is the most frequent demyelinating disorder of the central nervous system. It mainly affects young adults and it has been calculated that between 20% and 30% are of late onset (after the age of 40), presenting clinical features, a clinical course and prognosis which are specific to this disorder.
Between 1985 and 1994 we studied 297 cases of MS (diagnosed according to the criteria of Poser) and found that in 20.5% the illness had started when the patients were over the age the 40.
Certain aspects of the clinical features and course of the disorder were compared, taking the group of late onset cases and a randomized sample of 100 cases of early onset, showing that the symptoms and pyramidal signs were more frequent in the late onset group, whilst sensory and visual signs were commoner in the early onset group. In both groups there were more females. MS was defined according to Poser's criteria in 78.7% and 77% respectively. Chronic, primary and secondary progressive forms predominated in tire late onset group, whilst in the group with onset before the age of 40 there was a predominance of the exacerbating-remitting form.
多发性硬化症（MS）是中枢神经系统最常见的脱髓鞘疾病。它主要影响年轻人，据计算，20%至30%的患者为晚发型（40岁以后发病），具有该疾病特有的临床特征、临床病程和预后。
1985年至1994年间，我们研究了297例多发性硬化症患者（根据波泽标准诊断），发现20.5%的患者在40岁以后发病。
比较了晚发型病例组和100例早发型病例的随机样本在该疾病临床特征和病程的某些方面，结果显示晚发型组的症状和锥体束征更为常见，而早发型组的感觉和视觉体征更为常见。两组中女性均较多。分别有78.7%和77%的病例根据波泽标准确诊。晚发型组以慢性、原发性和继发性进展型为主，而40岁以前发病的组中以复发缓解型为主。
