Gracia-Naya M, Usón-Martín M, Serrano-González C, Sanz-Paris A
Servicio de Neurología, Hospital Miguel Servet, Zaragoza, España.
Rev Neurol. 1997 Dec;25(148):1892-6.
Recent studies show that a raised level of serum ferritin indicates a poor prognosis in CVA patients, as do the well-known hyperglycemia, dyslipemia and arterial hypertension. The evolution and prognosis of acute cerebrovascular accidents are determined by a series of factors, some of which can be modified. This leads to a search for factors which can be modified and therefore influence the course of the illness.
To determine the ferritin levels and other parameters during the course of the illness of patients with serious cerebral vascular pathology and evaluate their effect on prognosis.
A prospective study was carried out on patients diagnosed as having CVA, admitted to the Neurology Department of the Miguel Servet Hospital (Zaragoza) during 1994, and who were in neurological coma (Glasgow scale less than 7) during the first 24 hours, and unable to swallow. The levels of various plasma parameters were determined (glucose, cholesterol, ferritin, etc.) on admission and then every 10 days.
Plasma ferritin levels higher than those considered normal by the laboratory, in the first few hours after CVA, are an independent predictive factor suggesting unfavourable evolution of the vascular condition. Equally, raised ferritinemia in the first weeks after CVA indicates a worse prognosis. This laboratory test may be carried out on patients with acute CVA to obtain more information on which to base the prognosis.
最近的研究表明，血清铁蛋白水平升高表明CVA患者预后不良，众所周知的高血糖、血脂异常和动脉高血压也是如此。急性脑血管意外的演变和预后由一系列因素决定，其中一些因素是可以改变的。这就促使人们寻找可以改变的因素，从而影响疾病的进程。
确定严重脑血管病变患者病程中的铁蛋白水平和其他参数，并评估其对预后的影响。
对1994年入住米格尔·塞尔维特医院（萨拉戈萨）神经科、最初24小时处于神经昏迷状态（格拉斯哥评分低于7分）且无法吞咽的CVA确诊患者进行了一项前瞻性研究。入院时及之后每10天测定各种血浆参数（葡萄糖、胆固醇、铁蛋白等）水平。
CVA后最初几小时内，血浆铁蛋白水平高于实验室认为的正常水平是提示血管状况不良演变的独立预测因素。同样，CVA后最初几周内铁蛋白血症升高表明预后较差。对急性CVA患者进行这项实验室检查可获取更多预后依据信息。
