Prat R, Banzo J, Díaz F J
Servicio de Neurocirugía, Hospital Clínico Universitario, Zaragoza, España.
Rev Neurol. 1997 Dec;25(148):2002-5.
We discuss the diagnostic and therapeutic usefulness of the presence of somatostatin receptors (SR) in meningiomas.
The SR are membrane receptors, may be saturated, have great affinity and pharmacological specificity for somatostatin (SS) and its analogues. SR have been found in 100% of the meningiomas studied. The presence of a large number of SR in different tumours permits gammagraphic detection in vivo by marking SS analogues with 1-231-DTPA and subsequent visualization using a gamma camera. This study may help to differentiate between meningiomias and other tumour lines. Experiments using different SS analogues have shown different degrees of affinity of these SS analogues for the different receptors. In various animal models a potent inhibitor effect on tumour growth has been seen following SS and its analogues. Unlike in hypophyseal adenomas and endocrine gastro-entero-pancreatic tumours, neither SS nor its analogues have shown any direct inhibitory action on the growth of meningioma cell cultures. Quite the opposite occurs. A small but significant stimulation of growth was seen in the presence of SS.
We consider the detection of SR by isotopic marking of SS analogues is useful in the differential diagnosis of meningiomas. The therapeutic usefulness of the analogues of SS for treatment of meningiomas remains controversial. Further study of the different types of receptors and analogues is necessary.
我们探讨脑膜瘤中生长抑素受体（SR）存在的诊断及治疗价值。
SR是膜受体，可被饱和，对生长抑素（SS）及其类似物具有高亲和力和药理学特异性。在所有研究的脑膜瘤中均发现了SR。不同肿瘤中大量SR的存在使得通过用1-231-DTPA标记SS类似物并随后使用γ相机进行可视化，能够在体内进行γ闪烁显像检测。这项研究可能有助于鉴别脑膜瘤与其他肿瘤类型。使用不同SS类似物的实验表明这些SS类似物对不同受体具有不同程度的亲和力。在各种动物模型中，SS及其类似物对肿瘤生长具有强效抑制作用。与垂体腺瘤和内分泌胃肠胰腺肿瘤不同，SS及其类似物对脑膜瘤细胞培养物的生长均未显示出任何直接抑制作用。恰恰相反，在有SS存在的情况下观察到了轻微但显著的生长刺激。
我们认为通过SS类似物的同位素标记检测SR对脑膜瘤的鉴别诊断有用。SS类似物对脑膜瘤治疗的价值仍存在争议。有必要对不同类型的受体和类似物进行进一步研究。
