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Multiple developmental requirements of noisette, the Drosophila homolog of the U2 snRNP-associated polypeptide SP3a60.诺伊塞特（Noisette）的多种发育需求，它是U2 snRNP相关多肽SP3a60的果蝇同源物。
Mol Cell Biol. 1998 Apr;18(4):1835-43. doi: 10.1128/MCB.18.4.1835.
2
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The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent.果蝇U2 snRNP蛋白U2A'具有一种独立于SNF/U2B"的重要功能。
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6
Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.人剪接因子SF3a60和SF3a66中与SF3a120结合、17S U2 snRNP组装及前剪接体形成所需的结构域。
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7
Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf(+) gene dose effects.果蝇整合型U1/U2蛋白Snf独立于U1和U2小核核糖核蛋白颗粒发挥功能，这一点由snf(+)基因剂量效应揭示。
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14451-8. doi: 10.1073/pnas.96.25.14451.

本文引用的文献

1
Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo.hrp48基因发生突变，该基因编码一种果蝇异质性核糖核蛋白颗粒蛋白，会导致致死性和发育缺陷，并在体内影响P因子第三内含子的剪接。
Mol Cell Biol. 1997 Dec;17(12):7260-7. doi: 10.1128/MCB.17.12.7260.
2
The branchpoint residue is recognized during commitment complex formation before being bulged out of the U2 snRNA-pre-mRNA duplex.分支点残基在剪接前体复合物形成过程中被识别，然后从U2 snRNA-前体mRNA双链体中凸起。
Mol Cell Biol. 1997 Jul;17(7):3469-76. doi: 10.1128/MCB.17.7.3469.
3
Developmental testis-specific regulation of mRNA levels and mRNA translational efficiencies for TATA-binding protein mRNA isoforms.TATA 结合蛋白 mRNA 亚型在发育中的睾丸特异性调节 mRNA 水平和 mRNA 翻译效率。
Dev Biol. 1997 Apr 1;184(1):138-49. doi: 10.1006/dbio.1997.8514.
4
The Drosophila suppressor of sable protein binds to RNA and associates with a subset of polytene chromosome bands.果蝇黑貂蛋白的抑制因子与RNA结合，并与多线染色体带的一个子集相关联。
Mol Cell Biol. 1997 Apr;17(4):2291-300. doi: 10.1128/MCB.17.4.2291.
5
The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes.果蝇基因fs(2)cup与otu相互作用，以定义生殖系染色体的结构和功能所需的细胞质途径。
Development. 1997 Apr;124(7):1419-31. doi: 10.1242/dev.124.7.1419.
6
stand still, a Drosophila gene involved in the female germline for proper survival, sex determination and differentiation.静止不动，一种参与雌性生殖系以确保正常存活、性别决定和分化的果蝇基因。
Genetics. 1997 Apr;145(4):975-87. doi: 10.1093/genetics/145.4.975.
7
The alternative splicing factor PSI regulates P-element third intron splicing in vivo.可变剪接因子PSI在体内调节P因子第三内含子的剪接。
Genes Dev. 1997 Jan 1;11(1):129-38. doi: 10.1101/gad.11.1.129.
8
Vive la différence: males vs females in flies vs worms.差异万岁：果蝇与线虫中的雄性与雌性
Annu Rev Genet. 1996;30:637-702. doi: 10.1146/annurev.genet.30.1.637.
9
The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS.白色杏色抑制因子的哺乳动物同源物调控CD45外显子4和纤连蛋白IIICS的可变mRNA剪接。
J Biol Chem. 1996 Dec 6;271(49):31106-14. doi: 10.1074/jbc.271.49.31106.
10
Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development.在果蝇发育过程中，snf功能丧失和功能获得性突变均表明snRNP蛋白在调节性致死前体mRNA剪接中发挥作用。
Genetics. 1996 Sep;144(1):95-108. doi: 10.1093/genetics/144.1.95.

诺伊塞特（Noisette）的多种发育需求，它是U2 snRNP相关多肽SP3a60的果蝇同源物。

Multiple developmental requirements of noisette, the Drosophila homolog of the U2 snRNP-associated polypeptide SP3a60.

作者信息

Meyer V, Oliver B, Pauli D

机构信息

Department of Zoology and Animal Biology, University of Geneva, Switzerland.

出版信息

Mol Cell Biol. 1998 Apr;18(4):1835-43. doi: 10.1128/MCB.18.4.1835.

DOI:10.1128/MCB.18.4.1835
PMID:9528755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC121413/
Abstract

We report the cloning of the noisette gene (noi), which encodes the Drosophila melanogaster ortholog of a U2 snRNP-associated splicing factor, SF3a60 (SAP61) in humans and PRP9p in Saccharomyces cerevisiae. Antibodies raised against human SF3a60 recognized NOI in flies, showing a nuclear localization in all the stages examined, including the embryo, the dividing cells of imaginal discs, and the larval polyploid nuclei. NOI is expressed in somatic and germinal cells of both male and female gonads. By mobilization of P transposons, we have generated a large number of noi mutations. Complete loss of function resulted in lethality at the end of embryogenesis, without obvious morphological defects. Hypomorphic alleles revealed multiple roles of noi for the survival and differentiation of male germ cells, the differentiation of female germ cells, and the development of several adult structures.

摘要

我们报道了诺伊塞特基因（noi）的克隆，该基因编码果蝇中与人类U2 snRNP相关剪接因子SF3a60（SAP61）以及酿酒酵母中PRP9p直系同源的蛋白。针对人类SF3a60产生的抗体在果蝇中识别出NOI，在包括胚胎、成虫盘分裂细胞和幼虫多倍体细胞核在内的所有检测阶段均显示出核定位。NOI在雄性和雌性性腺的体细胞和生殖细胞中均有表达。通过P转座子的转位，我们产生了大量的noi突变。功能完全丧失导致胚胎发育末期致死，无明显形态缺陷。亚效等位基因揭示了noi在雄性生殖细胞的存活和分化、雌性生殖细胞的分化以及几种成虫结构的发育中的多种作用。