Suzuki K, Ogura T, Yokose T, Sekine I, Nagai K, Kodama T, Mukai K, Nishiwaki Y, Esumi H
Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Br J Cancer. 1998 Mar;77(6):1003-8. doi: 10.1038/bjc.1998.165.
There is accumulating evidence of an increased risk of familial clustering of cancer in the first-degree relatives of lung cancer probands. However, no explanation has been proposed for these epidemiological data. We reviewed 379 female non-small-cell lung cancer (NSCLC) patients to obtain their family histories of malignancy. Among them, nine female NSCLC patients with three or more relatives diagnosed with malignancy and 28 control patients without a family history of malignancy were selected to be analysed for instability at six different microsatellite loci. We observed microsatellite instability (MSI) more frequently in the patients with three or more family histories of malignancy (six out of nine, 67%) than the control patients (5 out of 28, 18%). The incidence of MSI in the former was significantly higher than that in the control (P=0.011: Fisher's exact test). We detected no significant difference in clinicopathological characteristics between the cases with MSI and those without MSI, except for their family histories of cancer. Our results show that a significantly higher rate of MSI is associated with familial clustering of malignancy. MSI could be one of the underlying mechanisms for familial clustering of malignancy in female NSCLC patients.
越来越多的证据表明，肺癌先证者的一级亲属患癌的家族聚集风险增加。然而，对于这些流行病学数据尚未提出任何解释。我们回顾了379例女性非小细胞肺癌（NSCLC）患者，以获取她们的恶性肿瘤家族史。其中，选择了9例有三名或更多亲属被诊断为恶性肿瘤的女性NSCLC患者和28例无恶性肿瘤家族史的对照患者，对六个不同微卫星位点的不稳定性进行分析。我们观察到，有三名或更多恶性肿瘤家族史的患者（9例中的6例，67%）比对照患者（28例中的5例，18%）更频繁地出现微卫星不稳定性（MSI）。前者的MSI发生率显著高于对照组（P=0.011：Fisher精确检验）。除了癌症家族史外，我们未发现MSI患者与非MSI患者之间在临床病理特征上有显著差异。我们的结果表明，MSI发生率显著较高与恶性肿瘤的家族聚集有关。MSI可能是女性NSCLC患者恶性肿瘤家族聚集的潜在机制之一。
