Houston A S, Kemp P M, Macleod M A, Francis J R, Colohan H A, Matthews H P
Department of Nuclear Medicine, Royal Hospital Haslar, Gosport, Hants, United Kingdom.
J Nucl Med. 1998 Mar;39(3):425-30.
The purpose of this work was to determine whether certain pathological groups and other groups at risk for neurological damage exhibited distinctive patterns of regional cerebral blood flow (rCBF) abnormality.
HMPAO SPECT images obtained from six groups of subjects were compared with a normal cortical rCBF atlas, based on multivariate, voxel-by-voxel methods. In each case, a significance image was outputted, highlighting voxels with deficits of > or =3 s.d. of normal. Abnormal patterns were examined for the six groups, which comprised a further 40 normal volunteers, 18 diver controls, 50 divers with decompression illness (DCI), 34 boxers, 23 schizophrenics and 21 subjects with Alzheimer's disease.
The percentages of abnormal cortical voxels for each group were 0.41%, 0.53%, 1.38%, 1.05%, 0.56% and 2.24%, respectively. The percentages of images in each group with at least one lesion of 10 or more connected abnormal voxels and at least 10 lesions of two or more connected voxels, respectively, were 8% and 8% (normal volunteers), 17% and 11% (diver controls), 38% and 38% (divers with DCI), 41% and 29% (boxers), 26% and 13% (schizophrenics) and 90% and 48% (subjects with Alzheimer's disease). This suggests that multiple small lesions are as common as single large lesions for divers with DCI but not for patients with Alzheimer's disease or schizophrenia. Large lesions are located predominantly in the parietal and inferior temporal regions for Alzheimer's disease, in the parietal and occipital regions for divers with DCI and boxers and in the inferior frontal region for schizophrenia.
It appears that the groups considered here do have different rCBF patterns and that the significance image is a useful way of demonstrating this fact.
本研究的目的是确定某些病理组以及其他有神经损伤风险的组是否表现出独特的局部脑血流（rCBF）异常模式。
基于多变量逐体素方法，将从六组受试者获得的HMPAO SPECT图像与正常皮质rCBF图谱进行比较。在每种情况下，输出一个显著性图像，突出显示正常标准差大于或等于3的体素。检查了六组的异常模式，这六组包括另外40名正常志愿者、18名潜水对照者、50名患有减压病（DCI）的潜水者、34名拳击手、23名精神分裂症患者和21名阿尔茨海默病患者。
每组异常皮质体素的百分比分别为0.41%、0.53%、1.38%、1.05%、0.56%和2.24%。每组中至少有一个由10个或更多相连异常体素组成的病灶以及至少10个由两个或更多相连体素组成的病灶的图像百分比分别为8%和8%（正常志愿者）、17%和11%（潜水对照者）、38%和38%（患有DCI的潜水者）、41%和29%（拳击手）、26%和13%（精神分裂症患者）以及90%和48%（阿尔茨海默病患者）。这表明对于患有DCI的潜水者，多个小病灶与单个大病灶一样常见，但对于阿尔茨海默病或精神分裂症患者并非如此。对于阿尔茨海默病，大病灶主要位于顶叶和颞下区域；对于患有DCI的潜水者和拳击手，大病灶位于顶叶和枕叶区域；对于精神分裂症，大病灶位于额下区域。
这里所考虑的组似乎确实具有不同的rCBF模式，并且显著性图像是证明这一事实的有用方法。
