Ishibashi M, Nonoshita M, Uchida M, Kojima K, Tomita N, Matsumoto S, Tanaka K, Hayabuchi N
Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.
J Nucl Med. 1998 Mar;39(3):473-5.
We describe a patient with multiple myeloma who was found to have diffuse bone marrow uptake of 201Tl. Magnetic resonance (MR) imaging of the lumbar spine demonstrated abnormal low signal intensity on T1-weighted images and abnormal high signal intensity on T2-weighted images. The bone marrow consisted of 68% plasma cells, and the serum immunoglobulin (Ig)G concentration was 7900 mg/dL. After receiving chemotherapy, the percentage of plasma cells and serum IgG concentration declined and there was a decrease in the bone marrow uptake of 201Tl. However, the MR abnormalities in the lumbar spine showed no change after chemotherapy. This patient illustrates a limitation of the use of MR imaging for evaluation of disease state in patients with multiple myeloma, and demonstrates the potential usefulness of 201Tl imaging in these patients.
我们描述了一名多发性骨髓瘤患者，该患者被发现201铊在骨髓中呈弥漫性摄取。腰椎的磁共振（MR）成像显示，在T1加权图像上信号强度异常低，在T2加权图像上信号强度异常高。骨髓中浆细胞占68%，血清免疫球蛋白（Ig）G浓度为7900mg/dL。接受化疗后，浆细胞百分比和血清IgG浓度下降，201铊的骨髓摄取也减少。然而，化疗后腰椎的MR异常没有变化。该患者说明了在评估多发性骨髓瘤患者疾病状态时使用MR成像的局限性，并证明了201铊成像在这些患者中的潜在用途。
