Nomura K, Hashimoto I
Department of Dermatology, Hirosaki University School of Medicine, Japan.
Dermatology. 1997;195(4):395-8. doi: 10.1159/000245997.
A 67-year-old man and an 84-year-old woman developed palmoplantar erythema following resolution of bullous pemphigoid (BP). Clinical manifestations of the palmoplantar lesions in these 2 patients ranged from prominent, well-demarcated erythematous areas with focal erosions and fissures to mild erythema. On histological examination, the palmoplantar erythema in one patient showed thin reticular strands of proliferating cells which connected with the epidermis and extended into the dermis, interwinding and anastomosing irregularly. The second patient showed similar mild changes with duct-like luminal formations. These histological findings were consistent with the diagnosis of eccrine syringofibroadenoma (ESFA). We speculate that these lesions developed as a result of the underlying inflammatory process in BP and conclude that ESFA associated with an inflammatory condition should be considered a new category of ESFA.
一名67岁男性和一名84岁女性在大疱性类天疱疮（BP）消退后出现掌跖红斑。这两名患者掌跖皮损的临床表现从伴有局灶性糜烂和裂隙的明显、边界清楚的红斑区域到轻度红斑不等。组织学检查显示，一名患者的掌跖红斑表现为增殖细胞形成的细网状条索，其与表皮相连并延伸至真皮，不规则地相互缠绕和吻合。第二名患者表现出类似的轻度改变，伴有导管样管腔形成。这些组织学表现符合小汗腺汗管纤维腺瘤（ESFA）的诊断。我们推测这些病变是由BP潜在的炎症过程所致，并得出结论，与炎症状态相关的ESFA应被视为ESFA的一种新类型。
