Othieno-Abinya N A
Department of Medicine, College of Health Sciences, University of Nairobi, Kenya.
East Afr Med J. 1997 Oct;74(10):671-2.
The process of carcinogenesis is complicated and in most cases requires several steps of cellular transformation resulting from various molecular signals brought about by interactions between carcinogens and the cellular genome. Cancers in which cellular transformation does not require numerous processes tend to occur in younger age groups while cancers of the advancing age tend to be those in which the process of cellular transformation occurs through complex molecular processes that require ample time for induction.
致癌过程很复杂,在大多数情况下,致癌物与细胞基因组相互作用产生的各种分子信号会导致细胞发生多个阶段的转化。细胞转化不需要经过多个过程的癌症往往发生在较年轻的年龄组,而老年癌症往往是那些细胞转化过程通过复杂分子过程发生的癌症,这些过程需要足够的时间来诱导。