Kalra V K, Blankenhorn D H
Biochim Biophys Acta. 1976 Aug 23;441(2):334-40. doi: 10.1016/0005-2760(76)90177-6.
Delipidated human sera enhances the incorporation of [2-14C]acetate, but not mevalonate, into digitonin-precipitable sterols of pigeon lymphocytes. Show Racer and White Carneau pigeons exhibit inherited differences in induction of sterol synthesis dissociated from inheritance of hypercholesterolemia. Moreover, lymphocytes of three familial hypercholesterolemic individuals, having serum cholesterol level in the normal range by drug therapy, exhibited a higher activation of sterol synthesis by delipidated sera when compared to cells of normal individuals. It is suggested that genetic abnormality in lymphocytes of familial hypercholesterolemic can be dissociated from hypercholesterolemia.
脱脂人血清可增强[2-¹⁴C]乙酸盐而非甲羟戊酸掺入鸽淋巴细胞中可被洋地黄皂苷沉淀的固醇。赛鸽和白卡诺鸽在固醇合成诱导方面表现出遗传差异，且与高胆固醇血症的遗传无关。此外，三名家族性高胆固醇血症患者经药物治疗后血清胆固醇水平在正常范围内，与正常个体的细胞相比，其淋巴细胞经脱脂血清处理后固醇合成的激活程度更高。这表明家族性高胆固醇血症患者淋巴细胞中的遗传异常可与高胆固醇血症相分离。
