Au W Y, Ma S K, Chan A C, Liang R, Lam C C, Kwong Y L
Department of Medicine, Queen Mary Hospital, Hong Kong, People's Republic of China.
Cancer Genet Cytogenet. 1998 Apr 1;102(1):50-3. doi: 10.1016/s0165-4608(97)00294-x.
Granulocytic sarcoma (GS) is a rare manifestation of acute myeloid leukemia (AML), blastic transformation of chronic myeloid leukemia, and the myelodysplastic syndromes. The mediastinum is an unusual site of presentation. We report a series of three female patients with mediastinal GS. They were characterized by the presence of large and bizarre blast cells and near tetraploidy on cytogenetic analysis. All three patients responded poorly to chemotherapy. Near tetraploid AML is a rare entity, usually present in male patients, and has not been associated with GS. The clinical and pathological similarities in these three cases suggest a distinct category of poor-risk AML for which more intensive treatment is needed.
粒细胞肉瘤（GS）是急性髓系白血病（AML）、慢性髓系白血病急变期以及骨髓增生异常综合征的一种罕见表现形式。纵隔是其不常见的发病部位。我们报告了一组3例纵隔GS的女性患者。她们的特征是存在大的奇异原始细胞，并且细胞遗传学分析显示接近四倍体。所有3例患者对化疗反应不佳。接近四倍体的AML是一种罕见的实体，通常见于男性患者，且与GS无关。这3例病例在临床和病理方面的相似性提示了一种独特的高危AML类别，对此需要更强化的治疗。
