Székács B, Vajó Z, Juhász I, Vaslaki L, Nagy V
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Acta Physiol Hung. 1997;85(1):17-28.
The autocrin-paracrin prostanoid system plays a major role in the enhancement or inhibition of renal tissue damage. Our hypothesis was that there might be circulating factors in the plasma with a capability to modify renal (glomerular) prostanoid synthesis. We measured the synthesis of prostacyclin 1-2 (PGI2) and thromboxan A-2 (TxA2) of isolated glomeruli, incubated in plasma samples obtained from hypertensive and diabetic (NIDDM) patients. It was found that these plasma samples decreased the renal PGI2/TxA2 ratio, mostly by decreasing glomerular PGI2 synthesis and, to a lesser extent, increasing the synthesis of TxA2. Our results demonstrate that circulating factors in hypertension and diabetes might play a role in renal damage seen in these conditions.
自分泌-旁分泌前列腺素系统在增强或抑制肾组织损伤方面起主要作用。我们的假设是，血浆中可能存在能够改变肾（肾小球）前列腺素合成的循环因子。我们测量了分离的肾小球中前列环素1-2（PGI2）和血栓素A-2（TxA2）的合成，这些肾小球在取自高血压和糖尿病（非胰岛素依赖型糖尿病）患者的血浆样本中孵育。结果发现，这些血浆样本降低了肾PGI2/TxA2比值，主要是通过降低肾小球PGI2合成，在较小程度上是通过增加TxA2合成。我们的结果表明，高血压和糖尿病中的循环因子可能在这些情况下出现的肾损伤中起作用。
