腹腔注射咪达唑仑对链脲佐菌素诱导的糖尿病大鼠血糖水平和血脂的影响。
The effects of the intraperitoneal administration of midazolam on blood glucose level and serum lipids in streptozotocin-induced diabetes in rats.
作者信息
Cuparencu B, Horák J, Orbai P, Horák A, Lenghel A
机构信息
Department of Pharmacology, Faculty of Medicine, University of Oradea, Romania.
出版信息
Acta Physiol Hung. 1997;85(1):83-8.
PMID:9530439
Abstract
In male Wistar rats rendered diabetic by streptozotocin administration, the intraperitoneal (i.p.) injection of midazolam (2.5-5.0 and 10 mg/kg) induced a significant reduction of hyperglycemia and hyperlipidemia. The plasma immunoreactive insulin level was slightly, but significantly increased. The lethality was diminished.
摘要
在通过注射链脲佐菌素诱导糖尿病的雄性Wistar大鼠中，腹腔注射咪达唑仑（2.5 - 5.0和10毫克/千克）可显著降低高血糖和高血脂。血浆免疫反应性胰岛素水平略有但显著升高。致死率降低。
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