Castillo A, Diaz-Valle D, Gutierrez A R, Toledano N, Romero F
Centro del Laser, Madrid, Spain.
J Refract Surg. 1998 Jan-Feb;14(1):61-3. doi: 10.3928/1081-597X-19980101-12.
Laser in situ keratomileusis (LASIK) is an effective procedure to correct myopia. It may have complications related to the flap, such as epithelial ingrowth and stromal melt.
We report on a patient who developed extensive epithelial ingrowth and partial keratolysis of the flap following LASIK. This complication was treated by lifting the flap and removing the epithelium from within the interface.
Progressive keratolysis (stromal melt) can result in irregular astigmatism and loss of vision as well as photophobia and ciliary injection. The pathogenesis is not completely understood although the epithelial ingrowth in the interface is always present, and epithelial-stromal interaction with production of proteases may be involved.
Epithelial ingrowth may develop in the lamellar interface after LASIK and be associated with melting of the edge of the flap. This undesirable complication can be successfully managed with early surgical removal of the epithelium and proper attachment of the flap.
准分子原位角膜磨镶术（LASIK）是矫正近视的一种有效手术。它可能会出现与角膜瓣相关的并发症，如上皮植入和基质溶解。
我们报告了一名患者，该患者在LASIK术后出现了广泛的上皮植入和角膜瓣部分溶解。通过掀起角膜瓣并清除界面内的上皮来治疗这一并发症。
进行性角膜溶解（基质溶解）可导致不规则散光和视力丧失，以及畏光和睫状充血。尽管界面中总是存在上皮植入，但其发病机制尚未完全明了，可能涉及上皮与基质相互作用并产生蛋白酶。
LASIK术后角膜瓣层间界面可能会发生上皮植入，并与角膜瓣边缘溶解相关。早期手术清除上皮并妥善固定角膜瓣可成功处理这一不良并发症。
