Wun T, Paglieroni T, Rangaswami A, Franklin P H, Welborn J, Cheung A, Tablin F
Division of Hematology and Oncology, UC Davis School of Medicine, Sacramento Medical Foundation Center for Blood Research, California 95817, USA.
Br J Haematol. 1998 Mar;100(4):741-9. doi: 10.1046/j.1365-2141.1998.00627.x.
Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anaemia. Platelets may play a role in this vasculopathy. Samples from 43 patients with sickle cell disease (SCD) were examined for evidence of platelet activation using fluorescent-labelled monoclonal antibodies and flow cytometry. There was increased expression of activation-dependent antigens on the platelets from patients with SCD compared to those from both Caucasian and African-American controls. In addition, SCD patients had increased levels of platelet microparticles. Platelets are activated in patients with sickle cell disease. The contribution of platelet activation to sickle cell pathophysiology is under active investigation in our laboratories.
血管闭塞和血管病变是镰状细胞贫血患者发病的主要原因。血小板可能在这种血管病变中起作用。使用荧光标记的单克隆抗体和流式细胞术，对43例镰状细胞病（SCD）患者的样本进行检测，以寻找血小板活化的证据。与白种人和非裔美国对照者相比，SCD患者血小板上活化依赖性抗原的表达增加。此外，SCD患者的血小板微粒水平升高。镰状细胞病患者的血小板被激活。血小板活化对镰状细胞病理生理学的作用正在我们实验室积极研究中。
