Shueng P W, Hsu W L, Jen Y M, Wu C J, Liu H S
Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan, ROC.
Int J Radiat Oncol Biol Phys. 1998 Mar 1;40(4):889-96. doi: 10.1016/s0360-3016(97)00906-1.
To investigate the role of neoadjuvant chemotherapy followed by radiotherapy in locally advanced cervical cancer.
This study cites all known literature on the subject in the English language. Articles were selected for analysis by MEDLINE and CANCERLINE computer searches. In Phase II trials, the response rates of some selective series were analyzed. However, This article will specially emphasize the result of all Phase III randomized trials.
Several investigators did obtain promising results from Phase II trials of neoadjuvant chemotherapy, mostly cisplatin-based combinations, followed by radiotherapy. However, most Phase III trials failed to demonstrate any benefit in terms of loco-regional relapse and/or survival by up-front chemotherapy.
The role of neoadjuvant chemotherapy remains to be defined, and the search for more active new agents must be continued. The neoadjuvant setting is still experimental and could not be recommended as a standard treatment at the present.
探讨新辅助化疗后放疗在局部晚期宫颈癌中的作用。
本研究引用了所有已知的关于该主题的英文文献。通过MEDLINE和CANCERLINE计算机检索选择文章进行分析。在II期试验中，分析了一些选择性系列的缓解率。然而，本文将特别强调所有III期随机试验的结果。
几位研究者确实从新辅助化疗的II期试验中获得了有前景的结果，大多是以顺铂为基础的联合化疗，随后进行放疗。然而，大多数III期试验未能证明 upfront 化疗在局部区域复发和/或生存方面有任何益处。
新辅助化疗的作用仍有待确定，必须继续寻找更有效的新药物。新辅助治疗仍处于试验阶段，目前不能推荐作为标准治疗方法。
