Liu Q, Shalaby F, Jones J, Bouchard D, Dumont D J
Amgen Institute, Toronto, Ontario, Canada.
Blood. 1998 Apr 15;91(8):2753-9.
Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies of Ship during mouse development. Results of this study demonstrate the expression of ship to be in late primitive-streak stage embryos (7.5 days postcoitus [dpc]), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in mouse embryo. In adult mice, Ship expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes, and lymphocytes, and is also found in the spermatids of the testis. Furthermore, the level of Ship expression is developmentally regulated during T-cell maturation. These results suggest a possible role for Ship in the differentiation and maintenance of the hematopoietic lineages and in spermatogenesis.
SHIP是一种最近发现的含SH2结构域的肌醇多磷酸5-磷酸酶，在细胞培养系统中它被认为是一种重要的信号分子。为了解SHIP在体内的生理功能，我们对小鼠发育过程中SHIP的表达进行了研究。这项研究结果表明，SHIP在原始条纹晚期胚胎（交配后7.5天[dpc]）中表达，此时造血作用被认为开始，并且该表达在小鼠胚胎中仅限于造血谱系。在成年小鼠中，SHIP表达继续存在于大多数造血来源的细胞中，包括粒细胞、单核细胞和淋巴细胞，并且在睾丸的精子细胞中也有发现。此外，SHIP表达水平在T细胞成熟过程中受到发育调控。这些结果表明SHIP在造血谱系的分化和维持以及精子发生中可能发挥作用。
