[抗氧化剂普罗布考：对自由基脂质过氧化、血液流变学及心绞痛病程的影响]
[Antioxidant probucol: effects on free radical lipid peroxidation, blood rheology and course of angina pectoris].
作者信息
Zakirova A N, Shamaev A G, Mirionkova N A
出版信息
Ter Arkh. 1998;70(1):29-32.
AIM
Study of the effect of antioxidant probucol on free-radical lipid peroxidation, blood rheology, and course of angina pectoris in coronary patients.
MATERIALS AND METHODS
The above parameters and clinical hemodynamic values were monitored over the course of probucol therapy in 48 men (mean age 54.8 +/- 1.3 years) with coronary disease and angina of effort of the II-III functional class.
RESULTS
Long therapy with probucol effectively inhibited free-radical lipid peroxidation, normalized lipid spectrum of the blood, and had a favorable impact on the course of angina pectoris.
CONCLUSION
Probucol stabilizes the structure and function of red cells and platelets in coronary patients.
目的
研究抗氧化剂普罗布考对冠心病患者自由基脂质过氧化、血液流变学及心绞痛病程的影响。
材料与方法
对48名患有冠心病且为II - III级功能性劳力性心绞痛的男性患者（平均年龄54.8 +/- 1.3岁）在普罗布考治疗过程中监测上述参数及临床血流动力学值。
结果
长期使用普罗布考可有效抑制自由基脂质过氧化，使血脂谱正常化，并对心绞痛病程产生有利影响。
结论
普罗布考可稳定冠心病患者红细胞和血小板的结构与功能。
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