[Intracellular distribution of hyaluronidase in rats with acute and chronic hepatitis and reparative liver regeneration].

Subcellular distribution of hyaluronidase of rat liver was studied during spontaneous restoration during the 1st, 2nd, 3rd days, and 1, 2, 3, 4 weeks of acute and chronic CCl4-hepatitis. Redistribution of relative specific activity of hyaluronidase was seen in the fractions of heavy and light mitochondria, microsomes and supernatant fraction, after an acute hepatic injury. Four weeks after the injury subcellular distribution was not yet normal. In chronic hepatitis the relative specific hyaluronidase activity was almost identical in the five subcellular fractions. In the course of restoration the relative specific activity was increased in the fractions of heavy and light mitochondria and microsomes, but decreased in the nuclear and supernatant fractions.