Treĭvish V S, Shoĭkhet I N, Ankova E V
Klin Med (Mosk). 1998;76(1):40-2.
Ketoconazole was used as an adjuvant to conventional 3-component immunosuppression in 56 patients with transplanted kidney. While receiving ketoconazole postoperative patients can be given reduced doses of cyclosporin (1.5-2 times). Long after the operation cyclosporin doses can be reduced 3-4-fold. Acute rejection occurred less frequently. This means that reduced cumulative steroid dose is needed for management of the rejection. In the dose above 100 mg/day, ketoconazole is able to enhance nephrotoxic effect of cyclosporin. A complication--acute renal dysfunction--is attributed to iatrogenic hypoaldosteronism induced by combination of large-dose cyclosporin + ketoconazole.
酮康唑被用作56例肾移植患者传统三联免疫抑制治疗的辅助药物。术后接受酮康唑治疗的患者可减少环孢素的剂量（减少1.5至2倍）。术后很长一段时间，环孢素的剂量可减少3至4倍。急性排斥反应的发生频率降低。这意味着在治疗排斥反应时所需的累积类固醇剂量减少。当酮康唑剂量高于100毫克/天时，它能够增强环孢素的肾毒性作用。一种并发症——急性肾功能不全——归因于大剂量环孢素与酮康唑联合使用所诱发的医源性醛固酮减少症。
