Pavlov S B
Urol Nefrol (Mosk). 1998 Jan-Feb(1):7-9.
Cu and Zn levels were measured (nuclear-absorption spectrophotometry) in the blood and urine from patients with chronic pyelonephritis (CP) in emergence of nephrosclerosis and renal insufficiency. CP patients were found to develop hypercupremia as early as initial stages of nephrosclerosis when renal insufficiency was not apparent. Blood Zn was low, especially in development of chronic renal insufficiency. Cu and Zn disbolism may contribute to formation of sclerotic lesions in the kidneys and to development of chronic renal insufficiency. Assay for Cu and Zn is proposed for early diagnosis of nephrosclerosis and provides objective clinical control over the disease course to make timely correction of the detected defects and valid prognosis.
采用核吸收分光光度法测定了慢性肾盂肾炎（CP）患者在出现肾硬化和肾功能不全时血液及尿液中的铜和锌含量。结果发现，CP患者早在肾硬化初期，即肾功能不全尚不明显时就出现了高铜血症。血液锌含量较低，尤其是在慢性肾功能不全发展阶段。铜和锌代谢可能促使肾脏硬化性病变的形成以及慢性肾功能不全的发展。建议检测铜和锌以早期诊断肾硬化，并为疾病进程提供客观的临床监测，以便及时纠正检测到的缺陷并做出有效的预后判断。
