Khalilov E M, Bol'shev V N
Biull Eksp Biol Med. 1976 Jun;81(6):668-70.
gamma-irradiation in doses of over 600 r proved to decrease the rate of androgen hydroxylation significantly; the rate of hydroxylation of the estrogens under study altered but little. Under the mentioned irradiation conditions the content of cytochrome P-450 in rat hepatic microsomes diminished. A reduction of the hydroxylation rate of steroid hormones by rat hepatic microsomes under the effect of total gamma-irradiation apparently depended on the qualitative changes of cytochrome P-450.
剂量超过600伦琴的γ射线照射被证明能显著降低雄激素的羟化速率；所研究的雌激素的羟化速率变化不大。在上述照射条件下，大鼠肝微粒体中细胞色素P - 450的含量减少。在全身γ射线照射的作用下，大鼠肝微粒体对甾体激素羟化速率的降低显然取决于细胞色素P - 450的质的变化。
