León F E, Suwazono S, Arimura K, Osame M
Departament of Neurology, University of Alabama at Birmingham 35294, USA.
Rev Neurol. 1998 Jan;26(149):64-6.
The physiological and pathological effects of cigarettes on the nervous system have been widely studied, but none of the investigations carried out has enabled us to determine the degree to which nicotine may affect the central pathways of somatosensorial evoked potentials in humans.
Following parameters established internationally for investigation of the effects of nicotine on the nervous system, we find that the N18 wave obtained by stimulation of the median nerve before smoking completely disappears after smoking for 3 minutes and reappears 10 minutes after smoking has stopped.
Therefore, we conclude that the action of nicotine on these evoked potentials is mainly subcortical, and for this reason it is essential to investigate the toxicological history before carrying out any clinical or neurophysiological study, since this might affect the results obtained.
香烟对神经系统的生理和病理影响已得到广泛研究，但此前进行的所有调查都未能使我们确定尼古丁可能影响人类躯体感觉诱发电位中枢通路的程度。
按照国际上确定的用于研究尼古丁对神经系统影响的参数，我们发现，吸烟前刺激正中神经所获得的N18波在吸烟3分钟后完全消失，并在停止吸烟10分钟后重新出现。
因此，我们得出结论，尼古丁对这些诱发电位的作用主要是皮层下的，因此在进行任何临床或神经生理学研究之前，调查毒理学史至关重要，因为这可能会影响所获得的结果。
