Brown A R, Cobb C M, Dunlap C L, Manch-Citron J N
Department of Oral & Maxillofacial Surgery, University of Missouri, Kansas City School of Dentistry, USA.
Compend Contin Educ Dent. 1997 Jul;18(7):724-6, 728-32, 734.
Papillary lesions of the oral cavity are extremely common, and inflammatory palatal hyperplasia is well known to dental practitioners. Advanced sophistication in viral laboratory technologies makes it apparent that various forms of the human papilloma virus are often causative. However, this is not true for inflammatory palatal hyperplasia. This article describes a patient with anatomically well-demarcated, multiple squamous cell papillomas of the palate that could not be classified as inflammatory palatal hyperplasia, nor could a viral etiology be ascertained, despite exhaustive laboratory studies. The lesion recurred despite numerous surgical ablation attempts. Eradication was achieved only after applying free soft-tissue grafts over the areas of excision. The differential diagnosis of papillary lesions with an emphasis on viral etiology, laboratory studies associated with their identification, and a hypothesis that explains why grafting was the only successful means of treatment are also discussed.
口腔乳头状病变极为常见，炎性腭部增生为牙科医生所熟知。病毒实验室技术的高度发展表明，多种形式的人乳头瘤病毒常为病因。然而，炎性腭部增生并非如此。本文描述了一名患者，其腭部存在解剖界限清晰的多发性鳞状细胞乳头状瘤，既不能归类为炎性腭部增生，尽管进行了详尽的实验室检查，也无法确定病毒病因。尽管多次尝试手术切除，病变仍复发。仅在切除区域应用游离软组织移植后才实现根除。文中还讨论了以病毒病因学为重点的乳头状病变的鉴别诊断、与其识别相关的实验室检查，以及一个解释为何移植是唯一成功治疗方法的假说。
