Hole D J, Gillis C R, McCallum I R, McInnes G T, MacKinnon P L, Meredith P A, Murray L S, Robertson J W, Lever A F
Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, UK.
J Hypertens. 1998 Jan;16(1):119-24. doi: 10.1097/00004872-199816010-00017.
To measure rates of incident and fatal cancer in hypertensive patients taking calcium antagonists and to compare these with rates in three control groups.
A retrospective analysis of cancer in patients of the Glasgow Blood Pressure Clinic prescribed either a calcium antagonist or other antihypertensive drugs (non-calcium antagonist group). Record linkage of the clinic with the West of Scotland Cancer Registry and with the Registrar General, Scotland provided information on incidence of cancer and on deaths and their causes.
2297 patients were prescribed calcium antagonist and 2910 were prescribed antihypertensive drugs other than calcium antagonist.
Relative risk of cancer, the ratio of observed to expected cancers in the calcium antagonist group, was estimated using expected values based on three control groups; namely the non-calcium antagonist group, a middle-aged population of Renfrew and Paisley and the West of Scotland population.
There were 134 incident cancers in the calcium antagonist group, representing relative risks of 1.02 [95% confidence interval (CI) 0.82-1.271 compared with the non-calcium antagonist group, 1.01 (95% CI 0.84-1.18) compared with Renfrew-Paisley controls and 1.02 (95% CI 0.85-1.19) compared with West of Scotland controls. Findings for cancer mortality were similarly negative. Risks were no higher for older patients.
Our study lends no support to the suggestion that calcium antagonists cause cancer.
测定服用钙拮抗剂的高血压患者的癌症发病率和死亡率，并与三个对照组的发病率和死亡率进行比较。
对格拉斯哥血压诊所中开具钙拮抗剂或其他抗高血压药物（非钙拮抗剂组）的患者的癌症情况进行回顾性分析。该诊所与苏格兰西部癌症登记处以及苏格兰总登记官进行记录链接，以获取癌症发病率、死亡情况及其原因的信息。
2297例患者开具了钙拮抗剂，2910例患者开具了非钙拮抗剂类抗高血压药物。
使用基于三个对照组（即非钙拮抗剂组、伦弗鲁和佩斯利的中年人群以及苏格兰西部人群）的预期值来估计钙拮抗剂组中癌症的相对风险，即观察到的癌症与预期癌症的比率。
钙拮抗剂组有134例新发癌症，与非钙拮抗剂组相比，相对风险为1.02[95%置信区间（CI）0.82 - 1.27]，与伦弗鲁 - 佩斯利对照组相比为1.01（95%CI 0.84 - 1.18），与苏格兰西部对照组相比为1.02（95%CI 0.85 - 1.19）。癌症死亡率的结果同样为阴性。老年患者的风险并不更高。
我们的研究不支持钙拮抗剂会导致癌症这一观点。
