[苯乙双胍对妊娠大鼠脂肪-碳水化合物代谢的影响]
[Effect of phenformin on fat-carbohydrate metabolism in pregnant rats].
作者信息
Bershteĭn L M, Aleksandrov V A
出版信息
Biull Eksp Biol Med. 1976 Jul;82(7):825-7.
PMID:953344
Abstract
Rats given phenphormin, an antidiabetic biguanide, from the 1st (8th) day of pregnancy displayed a fall of cholesterol, phospholipids and free fatty acids in the blood; no maldevelopment of the fetus or placenta was seen. Permissibility of prescription of biguanides during pregnancy is discussed.
摘要
从怀孕第1天（第8天）起给大鼠服用抗糖尿病双胍类药物苯乙双胍，可使血液中的胆固醇、磷脂和游离脂肪酸含量下降；未观察到胎儿或胎盘发育异常。文中讨论了孕期使用双胍类药物的处方可行性。
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