左氧氟沙星相较于环丙沙星，较少选择耐氟喹诺酮的耐甲氧西林金黄色葡萄球菌。
Levofloxacin selects fluoroquinolone-resistant methicillin-resistant Staphylococcus aureus less frequently than ciprofloxacin.
作者信息
Evans M E, Titlow W B
机构信息
Department of Internal Medicine, University of Kentucky School of Medicine, Lexington 40536-0084, USA.
出版信息
J Antimicrob Chemother. 1998 Feb;41(2):285-8. doi: 10.1093/jac/41.2.285.
Seventeen methicillin-resistant Staphylococcus aureus (MRSA) with unique genotypes were examined to determine if resistance occurs more frequently with ciprofloxacin or levofloxacin. The mean single-step resistance rate to 4 x MIC of ciprofloxacin was 1.05 x 10(-5) (range <4.82 x 10[-11] to 5.06 x 10[-5]), and that to levofloxacin was 4.03 x 10(-6) (range <3.57 x 10[-13] to 4.10 x 10[-5]) (P < 0.05). When serially passaged, the mean MICs of ciprofloxacin and levofloxacin increased 3.0 +/- 1.5-fold and 1.8 +/- 1.4-fold, respectively (P < 0.05). Only four strains became resistant to levofloxacin, but eight became resistant to ciprofloxacin (P < 0.05). Ciprofloxacin selects resistant MRSA more frequently than levofloxacin.
对17株具有独特基因型的耐甲氧西林金黄色葡萄球菌（MRSA）进行检测，以确定环丙沙星或左氧氟沙星导致耐药的情况是否更常见。对4倍MIC环丙沙星的平均单步耐药率为1.05×10⁻⁵（范围<4.82×10⁻¹¹至5.06×10⁻⁵），对左氧氟沙星的平均单步耐药率为4.03×10⁻⁶（范围<3.57×10⁻¹³至4.10×10⁻⁵）（P<0.05）。连续传代时，环丙沙星和左氧氟沙星的平均MIC分别增加3.0±1.5倍和1.8±1.4倍（P<0.05）。只有4株对左氧氟沙星耐药，但有8株对环丙沙星耐药（P<0.05）。与左氧氟沙星相比，环丙沙星更易筛选出耐药的MRSA。
Zotero 插件