Cook J D, Finch C A, Smith N J
Blood. 1976 Sep;48(3):449-55.
The iron status of a population of 1564 subjects living in the northwestern United States was evaluated by measurements of transferrin saturation, red cell protoporphyrin, and serum ferritin. The frequency distribution of these parameters showed no distinct separation between normal and iron-deficient subjects. When only one of these three parameters was abnormal (transferrin saturation below 15%, red cell protoporphyrin above 100 mug/ml packed red blood cells, serum ferritin below 12 ng/ml), the prevalence of anemia was only slightly greater (10.9%) than in the entire sample (8.3%). The prevalence of anemia was increased to 28% in individuals with two or more abnormal parameters, and to 63% when all three parameters were abnormal. As defined by the presence of at least two abnormal parameters, the prevalence of iron deficiency in various populations separated on the basis of age and sex ranged from 3% in adolescent and adult males to 20% in menstruating women. It is concluded that the accuracy of detecting iron deficiency in population surveys can be substantially improved by employing a battery of laboratory measurements of the iron status.
通过检测转铁蛋白饱和度、红细胞原卟啉和血清铁蛋白，对居住在美国西北部的1564名受试者的铁状态进行了评估。这些参数的频率分布显示，正常受试者和缺铁受试者之间没有明显区分。当这三个参数中只有一个异常时（转铁蛋白饱和度低于15%、红细胞原卟啉高于每毫升压积红细胞100微克、血清铁蛋白低于12纳克/毫升），贫血患病率仅略高于整个样本（8.3%），为10.9%。有两个或更多异常参数的个体贫血患病率增至28%，三个参数均异常时则增至63%。根据至少两个异常参数的存在来定义，按年龄和性别划分的不同人群中铁缺乏患病率从青少年和成年男性的3%到经期女性的20%不等。得出的结论是，通过采用一系列铁状态实验室检测方法，可大幅提高人群调查中铁缺乏检测的准确性。
