Bobet J, Mooney R F, Gordon T
Department of Physical Therapy, University of Alberta, Edmonton, Canada.
Muscle Nerve. 1998 Apr;21(4):536-9. doi: 10.1002/(sici)1097-4598(199804)21:4<536::aid-mus15>3.0.co;2-v.
It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20-21 months) mdx mice and age-matched controls. The mdx and control muscles generated similar twitch, tetanic, and eccentric forces. They were also equally stiff. The results show that the mechanics of aged mdx limb muscles differ greatly from Duchenne muscular dystrophy in humans, and disagree with the hypothesis.
最近基于组织病理学研究表明，老年mdx小鼠的肢体肌肉可能是人类杜氏肌营养不良症中所见肌肉变化的良好模型。为了验证这一假设，我们测量了老年（20 - 21个月）mdx小鼠和年龄匹配的对照小鼠的比目鱼肌和趾长伸肌（EDL）的力量和刚度。mdx小鼠和对照小鼠的肌肉产生了相似的单收缩、强直收缩和离心收缩力。它们的刚度也相同。结果表明，老年mdx小鼠肢体肌肉的力学特性与人类杜氏肌营养不良症有很大不同，与该假设不符。
