Moretta A, Parolini S, Castriconi R, Bottino C, Vitale M, Sivori S, Millo R
Dipartimento di Scienze Biomediche e Biotecnologie, Università di Brescia, Italy.
Eur J Immunogenet. 1997 Dec;24(6):455-68. doi: 10.1046/j.1365-2370.1997.d01-117.x.
In humans, natural killer lymphocytes express HLA class I-specific inhibitory receptors belonging to at least two different molecular families. The first is represented by members of the Ig superfamily that are involved in the recognition of different groups of HLA class I alleles, and the second is represented by a molecular complex formed by CD94 and NKG2A that displays a broad specificity for various class I molecules including the 'non-classical' HLA-G molecules. In addition to the inhibitory receptors, a series of activating receptors has been identified. Some display the same specificities as the corresponding inhibiting receptors and can be viewed as HLA class I-specific activating receptors. Another group of activating receptors appear to be involved in the cytolytic activity against HLA-'negative' target cells. These receptors are clearly non-MHC specific and, under physiological conditions, their function is suppressed by the HLA class I-specific inhibitory receptors.
在人类中，自然杀伤淋巴细胞表达至少属于两个不同分子家族的HLA I类特异性抑制性受体。第一个家族由免疫球蛋白超家族成员代表，它们参与识别不同组的HLA I类等位基因；第二个家族由CD94和NKG2A形成的分子复合物代表，该复合物对包括“非经典”HLA-G分子在内的各种I类分子具有广泛的特异性。除了抑制性受体外，还鉴定出了一系列激活受体。一些激活受体与相应的抑制性受体具有相同的特异性，可被视为HLA I类特异性激活受体。另一组激活受体似乎参与了对HLA“阴性”靶细胞的细胞溶解活性。这些受体显然是非MHC特异性的，在生理条件下，它们的功能被HLA I类特异性抑制性受体所抑制。
