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[带支架植入的主动脉冠状动脉静脉搭桥术治疗局灶性病变的近期及远期结果]

[Immediate and long-term results of treatment of focal lesions with aortocoronary venous bypass with a stent implant].

作者信息

Ramondo A, Bertaglia E, Fiocca L, Isabella G, Cardaioli P, Razzolini R, Chioin R

机构信息

Servizio di Emodinamica e Cardiologia Interventistica, Università degli Studi, Padova.

出版信息

Cardiologia. 1997 Dec;42(12):1271-6.

PMID:9534322
Abstract

Patients with recurrent angina after coronary artery bypass graft surgery pose a problem. Stent implantation has been advocated in an effort to avoid repeat operation and to address the limitations of balloon angioplasty. Aim of the present study was to determine the in-hospital and long-term results of stent deployment in focal, de novo lesions of vein grafts. Thirty-five focal, de novo lesions of vein grafts in 31 patients were treated with stent deployment. Twenty-four patients (77%) had three vessels, 6 (20%) two vessels and 1 (3%) single vessel disease. Saphenous vein grafts aged 9.7 +/- 4.2 years (range 1-19 years). Twenty-two lesions (63%) were located within the body of the saphenous graft, 8 (23%) at the graft/coronary artery anastomosis and 5 (14%) at the aorta/graft anastomosis. The indications for stent deployment included: suboptimal result from balloon angioplasty (defined as > or = 50% post-angioplasty residual stenosis) in 29/35 lesions (83%); post-angioplasty coronary dissection with threatening occlusion in 4/35 (11%); abrupt closure in 2/35 (6%). Patients were screened for death, myocardial infarction, bypass surgery and repeat angioplasty during in-hospital stay and after a follow-up of 12 +/- 8 months. Even-free survival curve was constructed by the Kaplan-Meier method. Stent deployment was successful in all patients. One stent was deployed in 24/35 lesions (69%), half Palmaz-Schatz stent in 6/35 (17%) and 2 or more stents in 5/35 (14%). The balloon/vessel ratio resulted of 1.0 +/- 0.1 Minimal lumen diameter increased from 0.8 +/- 0.4 to 3.8 +/- 0.6 mm, with a mean gain of 1.8 +/- 0.6 mm (range 1.8-4.0 mm). During the in-hospital period 1 patient (3.2%) died and 1 (3.2%) had a non Q wave myocardial infarction. Therefore, the clinical success rate, was 94%. During the follow-up period, 2 patients died (6.9%), 2 (6.9%) developed a non Q wave myocardial infarction, 1 (3.4%) underwent bypass surgery and 3 (10.3%) underwent repeat angioplasty. The estimated 2-year event-free survival rate (free from myocardial infarction, repeat surgery and repeat angioplasty) was 62%. In conclusion, Palmaz-Schatz stent deployment in focal, de novo vein grafts presents a high rate of procedural success, a low rate of acute complications and good long-term results.

摘要

冠状动脉搭桥手术后出现复发性心绞痛的患者是个难题。有人主张进行支架植入,以避免再次手术并解决球囊血管成形术的局限性。本研究的目的是确定在静脉移植物局灶性、初发性病变中植入支架的住院期间及长期结果。对31例患者的35处静脉移植物局灶性、初发性病变进行了支架植入治疗。24例患者(77%)有三支血管病变,6例(20%)有两支血管病变,1例(3%)有单支血管病变。大隐静脉移植物的年龄为9.7±4.2岁(范围1 - 19岁)。22处病变(63%)位于大隐静脉移植物主体内,8处(23%)位于移植物/冠状动脉吻合处,5处(14%)位于主动脉/移植物吻合处。支架植入的指征包括:29/35处病变(83%)球囊血管成形术效果欠佳(定义为血管成形术后残余狭窄≥50%);4/35处病变(11%)血管成形术后冠状动脉夹层并有威胁性闭塞;2/35处病变(6%)急性闭塞。在住院期间以及12±8个月的随访期内,对患者进行死亡、心肌梗死、搭桥手术及再次血管成形术的筛查。采用Kaplan - Meier法构建无事件生存曲线。所有患者支架植入均成功。24/35处病变(69%)植入1枚支架,6/35处病变(17%)植入半枚Palmaz - Schatz支架,5/35处病变(14%)植入2枚或更多支架。球囊/血管直径比为1.0±0.1。最小管腔直径从0.8±0.4毫米增加到3.8±0.6毫米,平均增加1.8±0.6毫米(范围1.8 - 4.0毫米)。住院期间,1例患者(3.2%)死亡,1例(3.2%)发生非Q波心肌梗死。因此,临床成功率为94%。随访期间,2例患者死亡(6.9%),2例(6.9%)发生非Q波心肌梗死,1例(3.4%)接受搭桥手术,3例(10.3%)接受再次血管成形术。估计2年无事件生存率(无心肌梗死、再次手术及再次血管成形术)为62%。总之,在静脉移植物局灶性、初发性病变中植入Palmaz - Schatz支架具有较高的手术成功率、较低的急性并发症发生率及良好的长期效果。

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