Arbous M S, Grobbee D E, van Kleef J W, Meursing A E
Julius Centre for Patient Oriented Research, Utrecht University, The Netherlands.
Anaesthesia. 1998 Feb;53(2):162-8. doi: 10.1046/j.1365-2044.1998.00303.x.
To date, anaesthesia-related mortality, morbidity and risk factors have almost exclusively been studied qualitatively rather than quantitatively. Therefore, knowledge of the relative risk associated with many anaesthesia-related factors is still lacking. Recently, a quantitative study of the determinants and prevention of morbidity and mortality in anaesthesia was started in the Netherlands. Its objective is to study severe peri-operative morbidity and mortality as a function of anaesthesia-related risk factors. The study is designed as a case-control study within a prospectively defined cohort. The cohort comprises all patients undergoing an anaesthetic procedure, either general, regional or a combination, in one of 61 hospitals between 1 January 1995 and 1 January 1997. A 'case' is a patient who dies within 24 h of undergoing an anaesthetic procedure or who remains comatose 24 h after an anaesthetic procedure. A 'control' patient is a randomly chosen patient who has undergone anaesthesia and is matched for gender and age. The present report discusses the study protocol.
迄今为止，几乎完全是从定性而非定量的角度来研究与麻醉相关的死亡率、发病率及风险因素。因此，对于许多与麻醉相关因素的相对风险仍缺乏了解。最近，荷兰启动了一项关于麻醉中发病率和死亡率的决定因素及预防的定量研究。其目的是研究严重围手术期发病率和死亡率与麻醉相关风险因素之间的关系。该研究被设计为在前瞻性界定队列中的一项病例对照研究。该队列包括1995年1月1日至1997年1月1日期间在61家医院之一接受全身麻醉、区域麻醉或联合麻醉的所有患者。“病例”是指在接受麻醉手术后24小时内死亡或在麻醉手术后24小时仍昏迷的患者。“对照”患者是随机选取的接受过麻醉且在性别和年龄上相匹配的患者。本报告讨论了该研究方案。
