英国药典方法测定卡比马唑片中甲巯咪唑（硫唑嘌呤）含量的研究。
Study of the British Pharmacopeia method on methimazole (thiamazole) content in carbimazole tablets.
作者信息
Aletrari M, Kanari P, Partassides D, Loizou E
机构信息
Pharmaceutical Quality Control, State General Laboratory, Ministry of Health, Nicosia, Cyprus.
出版信息
J Pharm Biomed Anal. 1998 Jan;16(5):785-92. doi: 10.1016/s0731-7085(97)00119-2.
PMID:9535190
Abstract
The analysis of carbimazole tablets in The British Pharmacopoeia, 1993, includes a quantitative thin layer chromatography (TLC) determination of methimazole. Repeated analysis of the same samples did not give similar results. The repeatability and reproducibility of the method was studied. It was proved that the residence time of the methimazole spot on the TLC plate is time dependent.
摘要
《1993年英国药典》中卡比马唑片的分析方法包括对甲巯咪唑的定量薄层色谱法（TLC）测定。对相同样品进行重复分析时，结果并不相似。因此对该方法的重复性和再现性进行了研究。结果证明，甲巯咪唑斑点在TLC板上的停留时间与时间有关。
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