嗜铬细胞和神经元中大型致密核心囊泡生物合成的调控。
Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons.
作者信息
Winkler H, Fischer-Colbrie R
机构信息
Department of Pharmacology, University of Innsbruck, Austria.
出版信息
Cell Mol Neurobiol. 1998 Apr;18(2):193-209. doi: 10.1023/a:1022516919932.
Abstract
- The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second messengers on the biosynthesis of LDV have been studied in detail. 3. Regulation of biosynthesis is complex. The cell can adapt to prolonged stimulation either by producing vesicles of normal size filled with a higher quantum of secretory peptides or by forming larger vesicles. In addition, some components, e.g., enzymes, can be upregulated specifically.
摘要
- 神经内分泌组织中大型致密核心囊泡（LDV）的蛋白质已得到充分表征。分泌成分包括嗜铬粒蛋白和神经肽。内在膜蛋白包括细胞色素b-561、转运蛋白、SV2、突触结合蛋白和突触小泡蛋白。2. 刺激和第二信使对LDV生物合成的影响已得到详细研究。3. 生物合成的调节很复杂。细胞可以通过产生充满更高数量分泌肽的正常大小囊泡或形成更大的囊泡来适应长时间刺激。此外，一些成分，如酶，可以被特异性上调。
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1
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Neurochem Int. 1990;17(2):245-62. doi: 10.1016/0197-0186(90)90147-l.
2
Enzymic systems involving adenosinephosphates in the adrenaline and noradrenaline containing granules of the adrenal medulla.肾上腺髓质中含肾上腺素和去甲肾上腺素的颗粒中涉及腺苷磷酸的酶系统。
Acta Physiol Scand. 1958 Feb 4;42(2):144-65. doi: 10.1111/j.1748-1716.1958.tb01548.x.
3
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4
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5
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6
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7
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