Lagae L G, Silberstein J, Gillis P L, Casaer P J
University Hospital Gasthuisberg; Department of Pediatrics; Leuven, Belgium.
Pediatr Neurol. 1998 Feb;18(2):165-8. doi: 10.1016/s0887-8994(97)00157-4.
A detailed history of a boy with Landau-Kleffner syndrome is presented, demonstrating a close relationship between language functioning and paroxysmal electroencephalogram activity. During a 3-year 6-month follow-up period, three abrupt deteriorations of all language functions occurred: the child became totally noninteractive with his environment within 1 week's time. Two of these deteriorations were reversed with steroid treatment, with an identical recovery phase. Intravenous immunoglobulins had a very dramatic and comparable effect in the third relapse; both language functions and electroencephalogram abnormalities were influenced significantly by the intravenous immunoglobulin treatment.
本文介绍了一名患有Landau-Kleffner综合征男孩的详细病史，证明了语言功能与阵发性脑电图活动之间的密切关系。在3年6个月的随访期内，出现了三次所有语言功能的突然恶化：患儿在1周内完全与周围环境失去互动。其中两次恶化经类固醇治疗后逆转，恢复阶段相同。静脉注射免疫球蛋白在第三次复发时产生了非常显著且类似的效果；静脉注射免疫球蛋白治疗对语言功能和脑电图异常均有显著影响。
