Trevisanuto D, Lachin M, Zaninotto M, Pellegrino P A, Plebani M, Cantarutti F, Zanardo V
Pediatric Department, University of Padova, Italy.
Biol Neonate. 1998;73(3):161-5. doi: 10.1159/000013973.
Cardiac troponin T (TnT) is a regulatory contractile protein whose detection in the circulation has been shown to be a specific and sensitive marker for ischemic myocardial cell injury both in adult and pediatric populations. We measured serum cardiac TnT in 15 consecutive full-term neonates presenting with bradycardia and electrocardiographic features of transient myocardial ischemia. Their median TnT concentrations (0.5 microg/l, range 0.01-0.37) were statistically comparable to our laboratory reference values for healthy term newborns (median 0.17 microg/l, range 0.01-0.42) (p = NS), but significantly higher with respect to our reference limits for healthy adults (median 0.01 micog/l, range 0.01-0.1) (p < 0.05). Our data demonstrate high TnT levels in neonates during the first days of life with respect to adults and similar TnT concentrations in term infants with and without TMI.
心肌肌钙蛋白T（TnT）是一种调节性收缩蛋白，在成人和儿童群体中，其在循环系统中的检测已被证明是缺血性心肌细胞损伤的特异性和敏感性标志物。我们对15例连续足月新生儿进行了血清心肌肌钙蛋白T检测，这些新生儿均表现出心动过缓和短暂性心肌缺血的心电图特征。他们的TnT浓度中位数为0.5微克/升（范围为0.01 - 0.37），与我们实验室健康足月新生儿的参考值（中位数0.17微克/升，范围0.01 - 0.42）在统计学上具有可比性（p = 无显著性差异），但相对于我们健康成年人的参考限值（中位数0.01微克/升，范围0.01 - 0.1）则显著更高（p < 0.05）。我们的数据表明，与成年人相比，新生儿在出生后的头几天TnT水平较高，且有和没有短暂性心肌缺血的足月婴儿的TnT浓度相似。
