地塞米松磷酸钠对早产儿造血祖细胞的体外作用
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants.
作者信息
Papoff P, Christensen R D, Harcum J, Li Y
机构信息
Department of Paediatrics, University of Florida College of Medicine, Gainesville, USA.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F67-9. doi: 10.1136/fn.78.1.f67.
Abstract
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.
摘要
研究了地塞米松对早产儿造血祖细胞克隆生长的体外作用。10⁻⁶M至10⁻⁹M的浓度与集落形成的剂量依赖性抑制相关，对最早的红系和粒-巨噬细胞集落的影响在临床上最为重要。鉴于这些观察结果可能具有的临床意义，需要开展研究以确定地塞米松对早产儿造血的影响。
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本文引用的文献
1
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2
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Eur J Clin Pharmacol. 1996;49(6):477-83. doi: 10.1007/BF00195934.
3
Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.获得性免疫缺陷综合征中的糖皮质激素与α干扰素
J Clin Endocrinol Metab. 1996 Jul;81(7):2601-6. doi: 10.1210/jcem.81.7.8675584.
4
Anti-inflammatory mechanisms of glucocorticoids.糖皮质激素的抗炎机制。
Biochem Soc Trans. 1995 Nov;23(4):940-5. doi: 10.1042/bst0230940.
5
Binding of glucocorticosteroids to hepatic erythropoietic cells of the rat fetus.糖皮质激素与大鼠胎儿肝脏造血细胞的结合。
J Endocrinol. 1981 May;89(2):307-15. doi: 10.1677/joe.0.0890307.
6
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Br J Haematol. 1983 Apr;53(4):621-8. doi: 10.1111/j.1365-2141.1983.tb07313.x.
7
Glucocorticoid receptor in chick erythrocytes.鸡红细胞中的糖皮质激素受体。
Life Sci. 1983 Oct 10;33(15):1485-9. doi: 10.1016/0024-3205(83)90851-2.
8
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J Pediatr. 1988 Jun;112(6):935-40. doi: 10.1016/s0022-3476(88)80223-3.
9
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