Reubi J C, Cuénod M
Brain Res. 1976 Aug 13;112(2):347-61. doi: 10.1016/0006-8993(76)90289-4.
A pathway having an affinity for glycine has been investigated in the pigeon optic lobe; it originates in the nucleus isthmi pars parvocellularis (Ipc) and terminates in the tectum, In an attempt to obtain evidence that glycine plays a role as a transmitter in this system, the effect of electrical stimulation on release of labeled substances previously injected in the tectum was tested. By perfusing the upper strata of the optic tectum with a push-pull cannula the release of radioactive glycine was shown to be markedly increased by electrical stimulation of Ipc, but not by stimulation of other sites. Ipc stimulation did not affect the efflux of exogenous leucine or urea, whereas a GABA release was observed. With K+ (40 mM) stimulation all amino acids tested were released. It is suggested that the Ipc neuron terminals in the tectum take up glycine and release it upon stimulation of the Ipc nucleus.
在鸽子视叶中对一条与甘氨酸有亲和力的通路进行了研究；它起源于峡核小细胞部（Ipc），并终止于顶盖。为了获得甘氨酸在该系统中作为神经递质起作用的证据，测试了电刺激对先前注入顶盖的标记物质释放的影响。通过用推挽式套管灌注视顶盖的上层，结果显示，电刺激Ipc可使放射性甘氨酸的释放显著增加，但刺激其他部位则无此效果。刺激Ipc并不影响外源性亮氨酸或尿素的流出，然而却观察到了γ-氨基丁酸（GABA）的释放。用40 mM的钾离子刺激时，所有测试的氨基酸都会释放。提示顶盖中的Ipc神经元终末摄取甘氨酸，并在刺激Ipc核时将其释放。
