Rabowsky J H, Dukes A J, Lee D A
Jules Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine 90095-7004, USA.
Eye (Lond). 1997;11 ( Pt 6):830-7. doi: 10.1038/eye.1997.214.
In a prospective and randomised study, we compared the course of pulsed dye laser ab interno sclerostomy with the course of posterior lip sclerectomy in 25 rabbits. One eye of each rabbit was randomly selected to be treated with laser; the fellow eye underwent posterior lip sclerectomy. Intraocular pressure (IOP) determinations and slit lamp examinations were recorded pre-operatively, then every other day for 3 weeks on 21 of the rabbits. Histological examination was performed on the eyes of 3 randomly selected rabbits that were killed 72 hours post-operatively. Laser sclerostomy resulted in an average maximal drop in IOP of 9.5 mmHg on post-operative day 1, and posterior lip sclerectomy resulted in a similar drop of 10.5 mmHg (p = 0.43, t-test). By life-table analysis, 88% of eyes returned to within 2 mmHg of pre-operative IOP values within 7 days following either laser internal sclerostomy or posterior lip sclerectomy. There was no significant difference between laser internal sclerostomy and posterior lip sclerectomy eyes with respect to the number of days needed to return to within 2 mmHg of preoperative IOP values (p = 0.26, sign test of the life-table analysis). Pulsed dye laser internal sclerostomy appears to be as effective as posterior lip sclerectomy in lowering IOP in the rabbit model.
在一项前瞻性随机研究中，我们比较了25只兔子脉冲染料激光内路巩膜造口术与后唇巩膜切除术的过程。每只兔子的一只眼睛被随机选择接受激光治疗；另一只眼睛进行后唇巩膜切除术。术前记录眼压（IOP）测定值和裂隙灯检查结果，然后在21只兔子中，术后每隔一天记录一次，持续3周。对术后72小时处死的3只随机选择的兔子的眼睛进行组织学检查。激光巩膜造口术术后第1天IOP平均最大降幅为9.5 mmHg，后唇巩膜切除术导致类似的10.5 mmHg降幅（p = 0.43，t检验）。通过寿命表分析，在激光内路巩膜造口术或后唇巩膜切除术后7天内，88%的眼睛IOP值恢复到术前值的2 mmHg以内。激光内路巩膜造口术和后唇巩膜切除术的眼睛在恢复到术前IOP值的2 mmHg以内所需天数方面没有显著差异（p = 0.26，寿命表分析的符号检验）。在兔模型中，脉冲染料激光内路巩膜造口术在降低IOP方面似乎与后唇巩膜切除术一样有效。
