Parker R G, Berkbigler D, Rees K, Leung K M, Legorreta A P
Department of Radiation Oncology, University of California at Los Angeles School of Medicine, 90095-6951, USA.
Am J Clin Oncol. 1998 Apr;21(2):109-10. doi: 10.1097/00000421-199804000-00001.
Intraductal carcinoma of the breast has become a well-defined entity that has been more frequently diagnosed since the introduction of mammography. For many years, the usual treatment has been mastectomy, often with axillary lymph node dissection. Concurrent with documentation that breast conservation treatment has been effective for many invasive breast cancers, such treatment has been introduced for noninvasive breast cancers (ductal carcinoma in situ and lobular cancer in situ). However, there is no basis for axillary dissection because tumor cells are contained by the basement membrane and should not metastasize. In this study, 107 axillary dissections were carried out, with an average of 20 nodes identified, and a single metastasis was identified.
乳腺导管内癌已成为一种明确的疾病实体,自乳腺钼靶检查引入以来,其诊断频率越来越高。多年来,常规治疗方法一直是乳房切除术,通常还会进行腋窝淋巴结清扫术。随着有文献证明保乳治疗对许多浸润性乳腺癌有效,这种治疗方法也被应用于非浸润性乳腺癌(导管原位癌和小叶原位癌)。然而,由于肿瘤细胞被基底膜包裹,不会发生转移,所以没有进行腋窝清扫的依据。在本研究中,共进行了107例腋窝清扫术,平均每例发现20个淋巴结,仅发现1例转移。